Abstract: The phenomenon of pyroptosis has gained increasing prominence in recent decades as a significant contributor to cellular mortality. The process of pyroptosis plays a crucial role in the regulation of various types of cancers. The induction of pyroptosis can be achieved through various mechanisms, including the activation of small molecule pyrogen inducers. The use of small molecule pyrogen inducer alone, however, has limitations. On one hand, we benefit from the utilization of nano delivery systems (NDS). On the other hand, there is an enhanced comprehension of the underlying mechanism governing pyroptosis. A novel therapeutic strategy, resulting from a clever amalgamation of the two approaches, has demonstrated significant efficacy in experimental treatment of certain diseases. A variety of nanocarriers, including liposomes, hydrogels, polymer micelles, exosomes, metal-organic frameworks protein nanoparticles, cell membrane biomimetic nanocarriers, carbon nanotubes, dendrimers, polymer conjugates and polymer nanoparticles are utilized for the delivery of drugs that induce pyroptosis in cells. By integrating the aforementioned approaches, a diverse range of pyroptosis strategies have been developed utilizing NDS, encompassing stem cell targeting, disruption of ion homeostasis, augmentation of reactive oxygen species generation, induction of epigenetic modifications, and transportation of gaseous protein gasdermins family proteins. However, the clinical application of these strategies still encounters numerous challenges that need to be addressed, including limited comprehension of NDS, incomplete understanding of the interaction mechanisms between nanomaterials and biological systems, and insufficient knowledge regarding nanocarrier materials. In this study, we aim to advance the field of pyroptosis in cancer treatment. The induction of pyroptotic cell death is believed to hold great promise as an ideal therapeutic approach for the management, regulation, and treatment of numerous types of cancers.