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    原发性干燥综合征病人睡眠障碍的相关因素分析

    Analysis of the related factors of sleep disorders in patients with primary Sjögren′s syndrome

      摘要
    • 摘要:
      目的 探讨原发性干燥综合征病人睡眠障碍现状及相关影响因素。
      方法 选取原发性干燥综合征病人150例为研究对象，运用匹兹堡睡眠质量指数量表(PSQI)调查病人睡眠质量状况，分析其相关影响因素。
      结果 睡眠障碍组和无睡眠障碍组PSQI总评分和伴随症状差异有统计学意义(P < 0.05);睡眠障碍组年龄、焦虑抑郁量表评分、疲劳严重度量表评分、ESSPRI评分、ESSDAI评分、红细胞沉降率、白细胞介素-6(IL-6)、IgG、IgA、IgM、抗核抗体定量较无睡眠障碍组高，C3较无睡眠障碍组低，差异有统计学意义(P < 0.05)。病人PSQI与年龄、焦虑抑郁量表、疲劳严重度量表、ESSPRI、ESSDAI、IL-6、红细胞沉降率、IgG、IgA、IgM及抗核抗体定量呈正相关关系(P < 0.05~ P < 0.01)，与C3呈负相关关系(P < 0.05)，而与C反应蛋白及C4无明显相关性。
      结论 原发性干燥综合征病人睡眠障碍发生率较高，且与年龄、焦虑抑郁情绪、疾病活动度等因素密切相关。

       

      Abstract:
      Objective To explore the current status of sleep disorders in patients with primary Sjögren′s syndrome and its related influencing factors.
      Methods One hundred and fifty patients with primary Sjögren′s syndrome were selected as the research subject.The Pittsburgh sleep quality index(PSQI) was used to investigate the sleep quality of patients, and the related influencing factors were analyzed.
      Results The differences of PSQI total score and accompanying symptoms between sleep disorder group and non-sleep disorder group were statistically significant(P < 0.05).The age, HADS score, FSS score, ESSPRI score, ESSDAI score, ESR, interleukin-6, IgG, IgA, IgM and quantitation of antinuclear antibody in the sleep disorder group were higher than those in non-sleep disorder group(P < 0.05), and the C3 in the sleep disorder group was lower than that in non-sleep disorder group(P < 0.05).The PSQI was positively correlated with the age, HADS, FSS, ESSPRI, ESSDAI ESR, interleukin-6, IgG, IgA, IgM and quantitation of antinuclear antibody(P < 0.05 to P < 0.01), negatively correlated with C3(P < 0.05), and not correlated with CRP and C4.
      Conclusions Patients with primary Sjögren′s syndrome have a high incidence of sleep disturbances, which are closely associated with factors such as age, anxiety and depressive symptoms, and disease activity.

       

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