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    冠状动脉钙化评分在缺血性脑卒中病人睡眠呼吸暂停预测中的作用

    Role of coronary artery calcification score in predicting sleep apnea in patients with ischemic stroke

      摘要
    • 摘要:
      目的 探讨冠状动脉钙化评分(CAC)在缺血性脑卒中病人睡眠呼吸暂停预测中的作用。
      方法 选择32例急性缺血性卒中病人作为研究对象, 纳入病人均接受冠状动脉多通道计算机断层扫描和多导睡眠图检查, 统计并分析血管危险因素、多导睡眠图检查结果和睡眠问卷评分与CAC评分的关系。
      结果 32例病人均存在一定程度的睡眠呼吸暂停, 平均呼吸紊乱指数(RDI)为(46.3±25.5)/h；其中轻度至中度睡眠呼吸暂停9例, 重度睡眠呼吸暂停23例。重度睡眠呼吸暂停病人的呼吸暂停指数、氧减饱和度指数(ODI)均高于轻度至中度睡眠呼吸暂停病人(P < 0.01), 而最低氧饱和度显低于轻度至中度睡眠呼吸暂停病人(P < 0.01)。CAC评分与RDI值(r=0.333, P < 0.05)、呼吸暂停指数(r=0.474, P < 0.01)和ODI(r=0.454, P < 0.05)呈正相关, 与最低氧饱和度(r=-0.381, P < 0.05)呈负相关。多变量线性回归分析显示, CAC评分与RDI (B= 5.302、P < 0.05), ODI(B=6.817, P < 0.05) 和STOP-BANG评分(B=90.303, P < 0.05)独立正相关。
      结论 CAC评分与缺血性脑卒中病人睡眠呼吸暂停的严重程度之间存在相关性。

       

      Abstract:
      Objective To investigate the role of coronary artery calcification (CAC) score in predicting sleep apnea in patients with ischemic stroke.
      Methods Thirty-two patients with acute ischemic stroke were selected as study subjects.Included patients underwent coronary multichannel computed tomography and polysomnography.The vascular risk factors, polysomnography results, and sleep questionnaire scores, and their association with CAC score were investigated.
      Results All patients were found to have sleep apnea of any degree mean RDI: (46.3±25.5)h; mild to moderate, n=9;severe, n=23.Apnea index and oxygen desaturation index (ODI) were significantly higher in patients with severe sleep apnea than those in the former (P < 0.01), while the minimum oxygen saturation was significantly lower than that in the former (P < 0.01).CAC score was positively correlated with RDI value (r=0.333, P < 0.05), apnea index (r=0.474, P < 0.01) and ODI (r=0.454, P < 0.05), and negatively correlated with minimum oxygen saturation (r=-0.381, P < 0.05).Multivariate linear regression analysis revealed that the CAC score was independent positively correlated with RDI(B= 5.302, P < 0.05), ODI (B=6.817, P < 0.05) and STOP-BANG score (B=90.303, P < 0.05).
      Conclusions There is a relationship between CAC score and the severity of sleep apnea in patients with ischemic stroke.

       

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