ARPP19、B4GALT3在宫颈癌组织中的表达及临床意义

王晓倩; 李慧; 张林风

doi:10.13898/j.cnki.issn.2097-5252.2025.02.019

ARPP19、B4GALT3在宫颈癌组织中的表达及临床意义

Expression and clinical significance of ARPP19 and B4GALT3 in cervical cancer

摘要

摘要:
目的探讨磷酸化蛋白19(ARPP19)、β-1, 4-半乳糖基转移酶Ⅲ(B4GALT3)在宫颈癌组织中的表达及与病人临床病理特征、预后的关系研究。
方法选取宫颈癌病人75例, 术中取其癌组织及癌旁组织, 免疫组织化学法检测ARPP19、B4GALT3蛋白表达, 分析ARPP19、B4GALT3与宫颈癌病人临床病理特征及预后关系, 并采用Spearman法分析宫颈癌组织中ARPP19、B4GALT3的相关性。
结果宫颈癌病人癌组织中ARPP19、B4GALT3蛋白阳性率高于癌旁组织(P < 0.01)。Spearman分析显示, 宫颈癌组织中ARPP19、B4GALT3呈正相关(r_s=0.511, P < 0.01)。ARPP19、B4GALT3蛋白表达与宫颈癌病人淋巴结转移、FIGO分期有关(P < 0.05~P < 0.01)。ARPP-19、B4GALT3阴性表达病人3年生存率分别为86.96%、88.00%, 均高于ARPP-19、B4GALT3阳性表达病人3年生存率(61.54%、60.00%), 差异有统计学意义(P < 0.05)。FIGO ⅡA期、淋巴结转移及ARPP-19、B4GALT3表达阳性是影响宫颈癌病人预后的独立危险因素(P < 0.05~P < 0.01)。
结论宫颈癌病人癌组织中ARPP19、B4GALT3蛋白阳性率显著增加, 二者呈正相关, 且均与病人临床病理特征有关。

Abstract:
Objective To investigate the expressions of phosphorylated protein 19(ARPP19) and β-1, 4-galactosyltransferase Ⅲ (B4GALT3) in cervical cancer tissues and its relationship with clinicopathological features and prognosis of patients.
Methods Seventy-five patients with cervical cancer were included, and their cancer tissues and adjacent tissues were collected during operation.The expressions of ARPP19 and B4GALT3 protein were detected by immunohistochemistry.The relationship between ARPP19, B4GALT3 and clinicopathological characteristics and prognosis of cervical cancer patients was analyzed, and Spearman method was used to analyze the correlation of ARPP19 and B4GALT3 in cervical cancer tissue.
Results The positive rates of ARPP19 and B4GALT3 proteins in cancer tissues of patients with cervical cancer were higher than those in adjacent tissues (P < 0.01).Spearman analysis showed that ARPP19 and B4GALT3 were positively correlated in cervical cancer tissue (r=0.511, P < 0.01).The expression of ARPP19 and B4GALT3 protein were related to lymph node metastasis, and FIGO stage of cervical cancer patients (P < 0.05 to P < 0.01).The 3-year survival rates of ARPP-19 and B4GALT3-negative patients were 86.96% and 88.00%, respectively, which were higher than those of ARPP-19 and B4GALT3-positive patients (61.54%, 60.00%), and the difference was statistically significant (P < 0.05).FIGO ⅡA stage, lymph node metastasis and positive expression of ARPP-19 and B4GALT3 were independent risk factors affecting the prognosis of cervical cancer patients (P < 0.05 to P < 0.01).
Conclusions The positive rates of ARPP19 and B4GALT3 proteins in cancer tissues of patients with cervical cancer are obviously increased, and the two are positively correlated.Both are related to the clinicopathological characteristics of patients, and are expected to become reference indicators for evaluating the prognosis of cervical cancer.

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