Objective To analyze the expressions of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and interferon-inducible protein 16 (IFI16) in pregnant women with preeclampsia (PE) and their relationship to placental blood flow changes and fetal growth restriction (FGR).

Methods Seventy-six pregnant women with PE combined with FGR were selected as the observation group.Eighty pregnant women with PE who underwent normal delivery during the same period were selected as the control group A. Eighty pregnant women who underwent normal delivery selected as the control group B.Serum sVCAM-1 and IFI16 levels were determined by enzyme-linked immunosorbent assay.Pearson correlation was applied to analyze the sVCAM-1, IFI16 and their correlation with placental blood flow parameters including pulsatility index (PI), resistance index (RI), and peak systolic/end-diastolic (S/D) flow.Multivariate logistic was applied to analyze the influencing factors of occurrence of FGR.

Results The serum levels of sVCAM-1, IFI16, S/D, RI and PI in control group B, control group A and observation group were obviously increased in turn (P < 0.01).Pearson correlation analysis showed that serum sVCAM-1 in PE patients was positively correlated to placental blood flow parameters S/D, RI and PI (P < 0.01), serum IFI16 was positively correlated with placental blood flow parameters S/D, RI, PI (P < 0.01), the serum levels of sVCAM-1 and IFI16 in PE patients were positively correlated (P < 0.01).Multivariate logistic analysis showed that serum sVCAM-1 and IFI16 were risk factors for FGR (P < 0.01).

Conclusions The expression levels of serum sVCAM-1 and IFI16 are up-regulated in PE patients, which are closely related to placental blood flow parameters, and both are risk factors for the occurrence of FGR.