冠心病病人PCI术后血清PDGFRβ和ICAM-1水平与预后的相关性

张磊; 栾绍华; 刘伟; 杨永忠

doi:10.13898/j.cnki.issn.2097-5252.2025.03.012

冠心病病人PCI术后血清PDGFRβ和ICAM-1水平与预后的相关性

Study on the correlation between serum PDGFRβ and ICAM-1 levels and prognosis in patients with coronary heart disease after PCI

摘要

摘要: 目的： 分析冠心病病人经皮冠状动脉介入治疗(PCI)术后血清血小板衍生生长因子受体β(PDGFRβ)和细胞间黏附分子-1(ICAM-1)水平与预后的相关性。方法： 选取接受PCI的160例冠心病病人作为研究对象,根据术后6个月心血管不良事件发生情况分为预后良好组90例和预后不良组70例。采用酶联免疫吸附法对病人PCI术后血清中PDGFRβ、ICAM-1水平进行检测；Spearman法分析冠心病病人PCI术后血清PDGFRβ和ICAM-1水平与预后的相关性；logistic回归分析影响PCI术后冠心病病人预后的因素；受试者工作特征(ROC)曲线分析血清PDGFRβ、ICAM-1水平对PCI术后冠心病病人预后的预测价值。结果： 与预后良好组相比,预后不良组冠心病病人PCI术后血清PDGFRβ、ICAM-1水平均明显升高(P<0.01)；冠心病病人PCI术后血清PDGFRβ、ICAM-1水平与预后均呈明显正相关关系(r=0.580,0.613,P<0.01)；logistic回归分析发现,冠状动脉Gensini评分高、C反应蛋白水平高、PDGFRβ水平高、ICAM-1水平高是PCI术后冠心病病人预后不良的危险因素(P<0.01),梗死相关动脉心肌梗死溶栓试验(TIMI)分级≥2级是PCI术后冠心病病人预后不良的保护因素(P<0.01)；血清PDGFRβ、ICAM-1联合预测PCI术后冠心病病人预后的ROC曲线下面积为0.948,均优于其各自单独预测(P<0.01和P<0.05)。结论： 冠心病病人PCI术后血清PDGFRβ、ICAM-1水平升高与病人预后有关,可较好地对冠心病病人PCI术后预后进行评估。

Abstract: Objective: To analyze the correlation between the serum levels of platelet-derived growth factor receptor β(PDGFRβ) and intercellular adhesion molecule-1(ICAM-1) and prognosis in patients with coronary heart disease after percutaneous coronary intervention(PCI). Methods: A total of 160 coronary heart disease patients treated with PCI were divided into the good prognosis group(90 cases) and poor prognosis group(70 cases) according to the occurrence of adverse cardiovascular events after 6 months of operation.The serum levels of PDGFRβ and ICAM-1 were detected by enzyme-linked immunosorbent assay.The Spearman method was used to analyze the correlation between the serum levels of PDGFRβ and ICAM-1 and prognosis in patients with coronary heart disease after PCI.The logistic regression analysis was used to analyze the factors affecting the prognosis of patients with coronary heart disease after PCI.The predictive value of serum levels of PDGFRβ and ICAM-1 on the prognosis of patients with coronary heart disease after PCI was analyzed using the ROC curve. Results: Compared with the good prognosis group,the serum levels of PDGFRβ and ICAM-1 in the poor prognosis group were obviously higher after PCI(P<0.01).The levels of serum PDGFRβ and ICAM-1 in patients with coronary heart disease after PCI were significantly positively correlated with prognosis(r=0.580,0.613,P<0.01).The results of logistic regression analysis showed that the high coronary artery Gensini score and high levels C-reactive protein,PDGFRβ and ICAM-1 were the risk factors affecting the prognosis of patients with coronary heart disease after PCI(P<0.01),and the myocardial infarction thrombolysis test (TIMI) grade ≥2 in infarct-related artery was a protective factor affecting the prognosis of patients with coronary heart disease after PCI(P<0.01).The area under the ROC curve of the combination of serum PDGFRβ and ICAM-1 in predicting the prognosis of patients with coronary heart disease after PCI was 0.948,which was better than that of individual prediction(P<0.05 and P<0.01). Conclusions: The increase of serum levels of PDGFRβ and ICAM-1 in patients with coronary heart disease after PCI is related to the prognosis of patients,which can better evaluate the prognosis of patients with coronary heart disease after PCI.

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