Abstract: Objective: To investigate the correlation between serum content of soluble nuclear factor-κB receptor activator ligand (sRANKL),soluble urokinase type plasminogen activator receptor (suPAR) and QRS wave time limit of electrocardiogram in patients with coronary heart disease. Methods: One hundred and thirty-three patients with coronary heart disease were selected as the observation group,and 100 healthy examinees at the same period as the control group.The QRS wave time limit of electrocardiogram and serum content of sRANKL and suPAR were compared between the two groups.The influencing factors of QRS wave time limit,and the correlation between serum content of sRANKL,suPAR and QRS wave time limit of electrocardiogram in patients with coronary heart disease were analyzed. Results: The serum content of sRANKL in the observation group was significantly lower than that in the control group (P<0.01),and the QRS wave time limit and serum content of suPAR in the observation group were significantly higher than those in the control group (P<0.01).Pearson correlation analysis showed that the serum content of sRANKL was negatively correlated with QRS wave time limit (r=-0.607,P<0.05),and the serum content of suPAR was positively correlated with QRS wave time limit in patients with coronary heart disease (r=0.588,P<0.05).Multiple linear regression analysis showed that sRANKL and suPAR were the influencing factors of QRS wave time limit in patients with coronary heart disease (P<0.01). Conclusions: The expression of sRANKL is down-regulated,and the expression of suPAR is up-regulated in the peripheral blood of patients with coronary heart disease.Both of them are correlated with the QRS wave time limit of electrocardiogram.SRANKL and suPAR may affect the QRS time limit and participate in the pathogenesis and progression of coronary heart disease.