乳腺癌病人超声参数与CA199、CA153的相关性分析

韩玥; 陈小雅; 刘春波; 郑淼; 王家富; 李津

doi:10.13898/j.cnki.issn.2097-5252.2025.03.020

乳腺癌病人超声参数与CA199、CA153的相关性分析

Correlation between ultrasound parameters and CA199,CA153, and their diagnostic value for breast lesions

摘要

摘要: 目的： 分析超声参数与血清糖类抗原199(CA199)、糖类抗原153(CA153)的相关性及对乳腺病变的诊断价值。方法： 选取90例乳腺病变病人为研究对象,根据乳腺病变性质分为良性组50例和恶性组40例。比较2组病人超声参数最大血流值(Vmax)、血流阻力指数(RI)、搏动指数(PI)及CA199、CA153水平,分析与Vmax、RI、PI与CA199、CA153间的相关性以及对乳腺病变的诊断价值。结果： 恶性组病人Vmax、RI、PI及CA199、CA153水平均明显高于良性组(P<0.01)。病人良恶性乳腺病变与Vmax、RI、PI、CA199、CA153水平均呈正相关关系(r=0.639、0.772、0.519、0.637、0.608,P<0.05~P<0.01)。乳腺病变病人Vmax、RI、PI与CA199水平均呈正相关关系(r=0.903、0.841、0.772,P<0.05~P<0.01),且与CA153水平均呈正相关关系(r=0.816、0.918、0.913,P<0.05~P<0.01)。ROC曲线分析显示,Vmax、RI、PI三项联合检测诊断恶性乳腺病变的AUC明显高于Vmax、RI、PI单项检测(P<0.01)。结论： 超声参数Vmax、RI、PI在乳腺病变病人中具有较高诊断价值,且与病人的CA199、CA153水平相关,可用于乳腺良恶病变的诊断。

Abstract: Objective: To analyze the correlation between ultrasound parameters and serum carbohydrate antigen 199 (CA199) and carbohydrate antigen 153 (CA153),and their diagnostic value for breast lesions. Methods: Ninety patients with breast lesions were selected as the study subjects,and were divided into a benign group (n=50) and a malignant group (n=40) based on the nature of the breast lesions.The ultrasound parameters such as maximum blood flow value (Vmax),resistance index (RI) and pulsatility index (PI),and CA199 and CA153 levels between the two groups were compared.The correlation between Vmax,RI,PI and CA199,CA153,and their diagnostic value for breast lesions were analyzed. Results: The Vmax,RI,PI,and levels of CA199 and CA153 in the malignant group were significantly higher than those in the benign group (P<0.01).Benignor malignant breast lesions of patients were positively correlated with Vmax,RI,PI,CA199,and CA153 levels (r=0.639,0.772,0.519,0.637,0.608,P<0.05 to P<0.01).The Vmax,RI,PI were positively correlated with CA199 levels in patients with breast lesions (r=0.903,0.841,0.772,P<0.05 to P<0.01),and also positively correlated with CA153 levels (r=0.816,0.918,0.913,P<0.05 to P<0.01).ROC curve analysis showed that the area under the curve for the combined detection of Vmax,RI,and PI in diagnosing malignant breast lesions was significantly higher than that of single detection of Vmax,RI,and PI (P<0.01). Conclusions: Ultrasound parameters Vmax,RI,and PI have high diagnostic value in patients with breast lesions,are correlated with the levels of CA199 and CA153 in patients,and can be used for the diagnosis of benign and malignant breast lesions.

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