Abstract: Objective: To explore the mediating effect of experiential avoidance,social support and kinesiophobia in patients with coronary heart disease. Methods: A total of 228 patients with coronary heart disease were selected as the study subjects,and evaluated using social support rating scale,acceptance and action questionnaire 2nd edition and Tampa scale for kinesiophobia heart. Results: The social support score of patients with coronary heart disease was (36.87±6.56) points,the experiential avoidance score was (24.58±3.39) points,and the total score of kinesiophobia was (41.17±5.31) points.Kinesiophobia was significantly negatively correlated with social support (r=-0.570,P<0.01),kinesiophobia was significantly positively correlated with experiential avoidance (r=0.572,P<0.01),and social support was significantly negatively correlated with experiential avoidance (r=-0.610,P<0.01).Experiential avoidance played a mediating role in social support and kinesiophobia,and the mediating effect was -0.205,accounting for 29.2% of the total effect. Conclusions: Experiential avoidance plays a mediating role between social support and kinesiophobia in patients with coronary heart disease.Social support can indirectly affect the level of kinesiophobia in patients with coronary heart disease through experiential avoidance.It is suggested that medical staffs should provide comprehensive support for patients with coronary heart disease in conjunction with family and social resources,to reduce the level of experiential avoidance,so as to alleviate kinesiophobia of patients and promote the exercise rehabilitation of patients.