Abstract: Objective: To investigate the correlation between serum TSH levels and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus. Methods: A total of 150 patients with type 2 diabetes mellitus hospitalized were selected and grouped according to their TSH levels,non-subclinical hypothyroidism(SCH) group(0.4 mIU/LResults: Compared with the non-SCH group,the urine albumin-to-creatinine ratio (UACR) level was elevated in the SCH group,with a statistically significant difference (P<0.01).The Cys-C level in SCH2 group was higher than the other two groups,and eGFR level was lower than the other two groups,with statistically significant differences (P<0.05).TSH showed a significant positive correlation with UACR (r=0.629,P<0.01) and a significant negative correlation with eGFR (r=-0.280,P<0.01).Binary logistic regression analysis showed that elevated TSH levels were an influencing factor in the development of diabetic nephropathy in patients with type 2 diabetes mellitus. Conclusions: Elevated serum TSH levels are a risk factor in the development of diabetic nephropathy in patients with type 2 diabetes mellitus with subclinical hypothyroidism.