Abstract: Objective: To investigate the expression of chemokines CCL3 and CCL4 in patients with pregnancy complicated with immune thrombocytopenia (ITP) and their effect on pregnancy outcome. Methods: A total of 113 pregnant women with ITP were selected as the oboservation group,and 100 healthy pregnant women with matched gestational weeks who underwent prenatal examination at the same time were selected as the control group.The expressions of CCL3 and CCL4 between the patients in the observation group and the subjects in the control group before and after treatment,as well as the incidence of adverse pregnancy outcomes and postpartum hemorrhage between the two groups were compared.At the same time,according to the situation of adverse pregnancy,the pregnant women in the observation group were divided into adverse pregnancy group and normal pregnancy group.The clinical data of the two groups were collected and compared,and the related factors affecting the pregnancy outcome of patients with ITP were analyzed by multivariate logistic regression. Results: The levels of serum CCL3 and CCL4 in the observation group were significantly higher than those in normal pregnant women before and after treatment (P<0.01).After treatment,the levels of CCL3 and CCL4 in the observation group were significantly lower (P<0.01).At the same time,the incidence of adverse pregnancy and postpartum hemorrhage in the observation group were significantly higher than those in normal pregnant women (P<0.05).Multivariate logistic regression analysis showed that the more severe thrombocytopenia,gestational diabetes mellitus,higher IgG level,higher CCL3 level and are higher CCL4 level were independent risk factors for adverse pregnancy outcomes in pregnant women with ITP (P<0.01). Conclusions: The serum levels of chemokines CCL3 and CCL4 in patients with pregnancy complicated with ITP are significantly increased,which can evaluate the patient's condition and treatment response,and are risks factor for predicting the adverse pregnancy outcome.