类风湿关节炎病人血清LRG1、sCD134、TNF-α水平与疾病活动度的相关性研究

刘琼; 王晓倩; 张志玲; 翟芳

doi:10.13898/j.cnki.issn.2097-5252.2025.04.021

类风湿关节炎病人血清LRG1、sCD134、TNF-α水平与疾病活动度的相关性研究

Study on the correlation between serum levels of LRG1, sCD134, TNF-α and disease activity in patients with rheumatoid arthritis

摘要

摘要:
目的探讨类风湿关节炎(RA)病人血清富亮氨酸α-2-糖蛋白1(LRG1)、可溶性CD134(sCD134)、肿瘤坏死因子-α(TNF-α)水平变化及其与疾病活动度的相关性。
方法选取收治的RA病人120例为RA组，并根据疾病活动度评分28(DAS28)将病人分为缓解组30例、低中度活动组61例、高度活动组29例，另选取同期进行治疗的非RA病人65例为非RA组，以及进行体检的40名健康者作为健康对照组。采用酶联免疫吸附法(ELISA)对各组血清LRG1、sCD134、TNF-α水平进行检测，并对健康对照组和RA组的临床资料进行比较；采用Pearson法分析RA病人血清LRG1、sCD134、TNF-α水平相关性；采用Spearman相关性分析法对病人血清LRG1、sCD134、TNF-α水平与DAS28评分相关性进行分析。
结果 RA组、非RA组血清LRG1、sCD134、TNF-α水平较健康对照组升高，且与非RA组相比，RA组血清LRG1、sCD134、TNF-α水平升高(P < 0.05)；健康对照组、RA组病人性别构成、年龄、体质量指数、收缩压、舒张压比较，差异均无统计学意义(P>0.05)；高度活动组、低中度活动组血清LRG1、sCD134、TNF-α水平和DAS28评分较缓解组升高，且与低中度活动组相比，高度活动组血清LRG1、sCD134、TNF-α水平和DAS28评分均升高(P < 0.05)；Pearson相关性分析结果显示，RA病人血清LRG1水平与sCD134、TNF-α水平及血清sCD134与TNF-α水平均存在明显的正相关关系(r=0.495、0.487、0.746，P < 0.01)；Spearman相关性分析结果显示，RA病人血清LRG1、sCD134和TNF-α水平与DAS28评分(疾病活动度)呈正相关关系(r=0.528、0.807、0.813，P < 0.01)。
结论 RA病人的血清LRG1、sCD134、TNF-α水平与其疾病活动度密切相关，检测病人血清LRG1、sCD134、TNF-α水平，对评估病人病情活动程度和治疗方案选择有一定参考价值。

Abstract:
Objective To investigate the serum levels changes of leucine rich-α-2-glycoprotein 1(LRG1), soluble CD134(sCD134), and tumor necrosis factor-α(TNF-α) in patients with rheumatoid arthritis(RA), and their correlation with disease activity.
Methods A total of 120 patients with RA were selected as RA group, and divided into the remission group(30 cases), low-moderate activity group(61 cases) and high activity group(29 cases) according to the disease activity score 28(DAS28).In addition, 65 non-RA patients at the same time were selected as the non-RA group, and 40 healthy physical examinees were selected as healthy control group.The serum levels of LRG1, sCD134 and TNF-α were detected by enzyme-linked immunosorbent assay(ELISA), and the clinical data between healthy control group and RA group were compared.The correlations of serum levels of LRG1, sCD134 and TNF-α in RA patients were analyzed by Pearson method.Spearman correlation analysis was used to analyze the correlation between the serum levels of LRG1, sCD134 and TNF-α and DAS28 score.
Results The serum levels of LRG1, sCD134 and TNF-α in the RA group and non-RA group were higher than those in healthy control group, and the serum levels of LRG1, sCD134 and TNF-α in the RA group were higher than those in non-RA group(P < 0.05).There was no statistical significance in the gender composition, age, body mass index, systolic and diastolic blood pressure between healthy control group and RA group(P>0.05).The serum levels of LRG1, sCD134, TNF-α and DAS28 score in the high activity group and low-moderate activity group were higher than those in remission group, and the serum levels of LRG1, sCD134, TNF-α and DAS28 score in the high activity group were higher than those in low-moderate activity group(P < 0.05).The results of Pearson correlation analysis showed that the serum LRG1 levels were significantly positively correlated with sCD134 and TNF-α levels, and the serum sCD134 levels were significantly positively correlated with TNF-α levels in RA patients(r=0.495, 0.487, 0.746, P < 0.01).The results of Spearman correlation analysis showed that the serum levels of LRG1, sCD134 and TNF-α were positively correlated with DAS28 score(disease activity) in RA patients(r=0.528, 0.807, 0.813, P < 0.01).
Conclusions The serum levels of LRG1, sCD134 and TNF-α in RA patients are closely related to the disease activity.Detecting the serum LRG1, sCD134, TNF-α levels of patients has certain reference value for evaluating the degree of disease activity and selecting treatment plan.

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