Abstract:
Objective To explore the changes of cognitive function and its influencing factors in patients with esophageal cancer before radical resection of esophageal cancer.
Methods The patients scheduled for esophageal cancer resection under general anesthesia were selected.The baseline data and preoperative Mini-mental State Examination(MMSE) scores of patients were collected.The patients were divided into the mild cognitive impairment (MCI) group and non-MCI group according to the preoperative MMSE score.Binary logistic regression analysis was used to analyze the influencing factors of cognitive function changes in patients with esophageal cancer.
Results A total of 183 patients with esophageal cancer were ultimately included, among whom 125 cases(68.31%) developed MCI.The results of univariate binary logistic regression analysis showed that the age(OR=1.06, 95%CI: 1.02-1.10, P < 0.01), educational level(primary school, OR=0.29, 95%CI: 0.12-0.71, P < 0.01), junior high school education and above, OR=0.30, 95%CI: 0.12-0.75, P=0.01) and history of alcohol consumption(OR=0.44, 95%CI: 0.23-0.84, P=0.01) were the factors influencing preoperative MCI in patients with esophageal cancer.The results of multivariate binary logistic regression analysis showed that the age(OR=1.05, 95%CI: 1.01-1.09, P=0.03) and educational level(primary school, OR=0.35, 95%CI: 0.14-0.88, P=0.03) were the independent influencing factors of preoperative MCI in patients with esophageal cancer.
Conclusions Patients with esophageal cancer have a relatively high probability of developing MCI before radical resection of esophageal cancer.The age and educational level are the independent influencing factors of MCI before surgery.The perioperative medical team can formulate targeted treatment or preventive strategies based on risk factors to improve patients′ cognitive function, and thereby enhance the quality of early postoperative rehabilitation.