Abstract: Objective: To explore the influencing factors of postoperative emergence delirium in children with oral comfort therapy. Methods: A retrospective cohort study design was adopted to screen the clinical data of children with oral comfort therapy at the Stomatological Hospital Affiliated to Anhui Medical University from November 2022 to November 2024.Among them, there were 52 cases in the dezocine group and 44 cases in the sufentanil group.Multivariate logistic regression analysis was used to determine the influencing factors of emergence delirium in children treated with oral comfortable therapy. Results: The use of dezocine during the induction period(OR=0.099, 95%CI: 0.026-0.375, P < 0.01) and preoperative PSAS score of children(OR=4.965, 95%CI: 2.415-10.208, P < 0.01) were the influencing factors of emergence delirium in children with oral comfortable therapy. Conclusions: The preoperative anxiety in children is the independent risk factor of emergence delirium in children with oral comfortable emergence therapy.The use of dezocine durng anesthesia induction can reduce its incidence.