Abstract: Objective: To investigate the psychological adaptation of caregivers of hospitalized patients with gastrointestinal cancer and explore its influencing factors. Methods: A questionnaire survey was conducted on 144 caregivers of hospitalized gastrointestinal cancer patients.The questionnaire included a general information questionnaire,a psychological adaptation scale,a social support assessment scale,and a simplified coping style scale.Multiple linear regression was used to analyze the influencing factors of their psychological adaptation. Results: The total score of psychological adaptation for 144 caregivers was (61.09±18.41) points.The total score and its various dimensions of psychological adaptation for caregivers were positively correlated with the total score and its various dimensions of social support for caregivers (P<0.01).The total score of psychological adaptation and its various dimensions were positively correlated with the total score of simplified coping style and the positive coping dimension score of caregivers (P<0.01),and negatively correlated with the negative coping dimension score (P<0.01).The results of multiple linear regression analysis showed that the level of patient awareness,self-care ability,average monthly income of caregivers,presence or absence of chronic diseases,and their social support status were the influencing factors of psychological adaptation for hospitalized gastrointestinal cancer patients (P<0.05 to P<0.01). Conclusions: The psychological adaptation of caregivers of hospitalized patients with gastrointestinal cancer is at a moderate level.Medical staff should comprehensively consider its related influencing factors and develop targeted intervention measures to further improve the psychological adaptation level of caregivers.