Abstract: Objective: To explore the application effects of International Classification of Functioning, Disability and Health(ICF) theory-guided information walking exercise program in maintenance hemodialysis patients. Methods: Eighty patients treated with regular hemodialysis were selected as the study subjects, According to the coin-tossing method, they were randomly divided into the observation group and the control group, with 40 cases in each group.The control group was intervened with the conventional hemodialysis nursing plan, and the observation group was intervened with the information walking exercise program guided by the ICF theory on the basis of the control group.The exercise indicators, exercise benefits/obstacles(DPEBBS) and frailty(FRAIL) before and after intervention were compared between two groups. Results: The daily walking number in the observation group was significantly higher than that in control group after intervention(P < 0.01).After 6 months of intervention, the 6 min walking distance(6-MWT), walking speed and STS-10 in the observation group were significantly better than those in control group(P < 0.01), and were better than those before intervention(P < 0.05 to P < 0.01).After intervention, the 6-MWT in the control group increased compared with before intervention(P < 0.01), and there was no statistical significance in the walking speed and STS-10 between before and intervention(P>0.05).After 3 months and 6 months of intervention, the exercise benefit of observation group was higher than that of control group, and the exercise obstacle was lower than that of control group(P < 0.05 and P < 0.01).After intervention, all dimensions of DPEBBS in two groups were improved compared with those before intervention(P < 0.05 and P < 0.01).After 6 months of intervention, the FRAIL of the observation group was significantly better than that of control group(P < 0.05).Conclusions: The information walking exercise program guided by ICF theory can improve the movement index of patients, increase the benefit of exercise, reduce the obstacle of exercise, and significantly improve the frailty condition.