Abstract: Objective: To explore the application effects of nursing intervention scheme based on shared decision-making concept in non-dialysis patients with chronic kidney disease(CKD). Methods: A total of 80 CKD patients were selected by convenience sampling method, and randomly divided into the observation group and control group by coin toss(40 cases in each group).The control group received routine care for CKD, while the observation group received a nursing intervention scheme based on the shared decision-making concept.The patients' preparation decision making (PrepDM), self-management and fear of progression questionnaire-short form (FoPQ-SF) were followed up, and collected before the intervention, at 1 month and 3 months after discharge. Results: At two time points after intervention, the PrepDM score, each dimension and total scores of self-management in the observation group were higher than those in control group(P < 0.05), and the PrepDM score, each dimension and total scores of self-management in the observation group showed an upward trend(3 months after discharge>1 month after discharge>before the intervention) (P < 0.05).After the intervention, two dimensions and total score of FoPQ-SF in the observation group were lower than those in control group(P < 0.01) and before the intervention(P < 0.05).The upward trend of each dimension of self-management in the control group was relatively slow(3 months after discharge>before intervention)(P < 0.05), and the physical health and total score were lower than those before intervention(P < 0.01).After the intervention, the proportion of patients with a total FoPQ-SF score ≥34 points in the observation group was lower than that in control group(P < 0.05).Conclusions: After the nursing intervention scheme based on the shared decision-making concept, the improvement of each indicator is significantly higher than that of the conventional nursing intervention program.Patients' decision-making preparation and self-management improve, and fear of disease progression decreases.