Abstract: Objective: To investigate the effects of geniposide on periodontal inflammation and gingival angiogenesis,and to preliminarily explore its mechanism of action based on the IKK/NF-κB signaling pathway. Methods: A rat model of experimental periodontitis was established using the ligation method.Forty successfully modeled rats were randomly divided into a model group and low,medium,high geniposide groups,with 10 rats in each group.The rats in the low,medium,high geniposide groups were administered 5,10,20 mg/kg geniposide via gavage,respectively.An additional 10 rats were selected as the control group and did not undergo modeling.Micro-CT imaging was used to evaluate alveolar bone resorption,bone mineral density (BMD),and bone volume/tissue volume (BV/TV) in each group.Western blotting and immunohistochemistry were employed to analyze histopathological damage and expression of related proteins in each group. Results: Compared with the control group,the model group exhibited decreased BMD and BV/TV,while the alveolar bone resorption and protein expression of TNF-α,IL-1β,PECAM,VEGF,p-IKKα,p-IKKβ,p-IκB,and p-NF-κB p65 in gingival tissues were significantly increased (P<0.05).Compared with the model group,the low,medium,and high dose geniposide groups showed increased BMD and BV/TV,along with reduced alveolar bone resorption and decreased expression of TNF-α,IL-1β,PECAM,VEGF,p-IKKα,p-IKKβ,p-IκB,and p-NF-κB p65 in gingival tissues (P<0.05). Conclusions: Geniposide facilitates the repair of alveolar bone loss and inhibits the periodontal inflammatory response in rats with periodontitis,the mechanism of which may be associated with the suppression of IKK/NF-κB signaling pathway.