Abstract: Objective: To investigate the value of pericoronary fat attenuation index(FAI) combined with atherogenic index of plasma(AIP) in predicting coronary vulnerable plaques. Methods: Patients with coronary heart disease(CHD) detected by coronary computed tomography angiography(CCTA) were retrospectively collected.The patients were divided into the non-vulnerable plaque group(58 cases) and vulnerable plaque group(42 cases) based on the presence or absence of vulnerable plaques in the coronary arteries.The differences in FAI,AIP and other data between two groups were compared.The logistic regression was used to analyze the influencing factors of vulnerable plaques.The predictive value of FAI and AIP for vulnerable plaques was evaluated by ROC curve. Results: The left ventricular ejection fraction,uric acid,FAI and AIP in the vulnerable plaque group were significantly higher than those in non-vulnerable plaque group(P<0.05 to P<0.01).The results of multifactorial logistic regression analysis showed(OR=1.265,P<0.01) and AIP(OR=24.551,P<0.05) were the independent risk factors of vulnerable plaques.The area under the curve (AUC) of FAI and AIP for predicting the vulnerable plaques were 0.856 and 0.665,respectively.The AUC of the combined prediction of vulnerable plaques by FAI and AIP was 0.874,which was superior to the predictive value of individual indicator(P<0.05). Conclusions: FAI and AIP are the independent risk factors of the occurrence of vulnerable plaques in coronary arteries.They have good diagnostic value in predicting vulnerable plaques,and the combined diagnostic efficacy of the two is superior to the individual predictive value of each index.