Abstract: Objective: To investigate the status quo of hope level,psychological resilience and coping style in non-small cell lung carcinoma(NSCLC) patients treated with immunotherapy,and mediating effects of hope level between psychological resilience and coping style. Methods: A total of 124 NSCLC patients treated with immunotherapy were selected using the convenience sampling,and investigated using the general information questionnaire,Herth hope scale,medical coping style questionnaire and psychological resilience scale. Results: The scores of hope level,psychological resilience and medical coping style of NSCLC patients treated with immunotherapy were (36.84±4.01) points,(60.12±16.08) points and (43.01±5.51) points,respectively.Through structural equation test,it was found that hope level had a partial mediating effect between psychological resilience and coping style,and the mediating effect accounted for 45.93% of total effect. Conclusions: For the NSCLC patients treated with immunotherapy,the hope level can improve the psychological resilience of patients,so that the patients adopt a positive attitude to cope with the disease,and play a part in mediating the role.