Abstract: Objective: To understand the current situation of early out-of-bed activities in patients treated with laparoscopic cholecystectomy(LC),and analyze its influencing factors. Methods: By using the convenience sampling method,139 patients treated with LC were selected as the research subjects.The general information,disease information,postoperative physical pain,fatigue,nausea,vomiting and situation of out-of-bed activities of LC patients were collected,and the factors influencing early out-of-bed activities of patients were analyzed. Results: Among the 139 LC patients,the first time of out-of-bed in 46 cases was found,and the early out-of-bed rate was 33.09%.The differences of the scores of drainage tube usage and removal time,urinary catheter usage and removal time,postoperative pain,fatigue,nausea,vomiting and fall history,preoperative physical strength and upright intolerance,and willingness to get out of bed early after surgery were statistically significant between two groups(P<0.05 to P<0.01).The results of logistic regression analysis showed that the indwelling drainage tube,postoperative pain,preoperative physical strength,upright intolerance and willingness of early out-of-bed activities after surgery were the independent influencing factors of postoperative early out-of-bed activities in LC patients(P<0.05 to P<0.01). Conclusions: The early out-of-bed rate of LC patients after surgery needs to be improved.Clinically,the attention should be paid to screening patients with low preoperative physical activity levels.After surgery,the attention should be paid to patients with indwelling drainage tube and those prone to upright intolerance.Early intervention should be carried out to enhance the patients' willingness of early out-of-bed activities around after surgery.