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    随访tCO2水平与维持性血液透析病人全因死亡的关系

    Study on the relationship between follow-up tCO2 levels and all-cause death in maintenance hemodialysis patients

      摘要
    • 摘要:
      目的 探讨随访二氧化碳总含量(tCO2)水平与维持性血液透析(MHD)病人全因死亡的关系。
      方法 收集MHD病人的随访资料，观察心血管及全因死亡发生情况。
      结果 207例病人观察至随访终点，中位随访时间29(15，36)个月，37例病人发生心血管或全因死亡。多因素COX回归分析
      结果 显示，随访tCO2水平≤21.80 mmol/L、高血压史、校正血总钙是MHD病人全因死亡的独立危险因素(P < 0.05~P < 0.01)，随访tCO2水平≤21.80 mmol/L的MHD病人全因死亡显著增加(P < 0.01)。
      结论 随访tCO2水平≤21.80 mmol/L是MHD病人死亡的独立影响因素。监测随访tCO2水平对预测MHD病人的死亡发生具有一定临床意义。提高血tCO2水平可以减少MHD病人死亡的发生。

       

      Abstract:
      Objective To observe the relationship between the follow-up total carbon dioxide(tCO2) levels and all-cause death in maintenance hemodialysis(MHD) patients.
      Methods The follow-up data of MHD patients were collected, and the cardiovascular and all-cause death were observed.
      Results Two hundred and seven patients were observed to the end point of follow-up, with a median follow-up time of 29(15, 36) months, and 37 patients had cardiovascular or all-cause death. The results of multivariate COX regression analysis showed that the follow-up tCO2 level ≤21.80 mmol/L, hypertension, and follow-up serum total calcium level were the independent risk factors of all-cause death in MHD patients(P < 0.05 to P < 0.01), the all-cause death in MHD patients with follow-up tCO2 level ≤21.80 mmol/L significantly increased(P < 0.01).
      Conclusions The follow-up tCO2 level ≤21.80mmol/L is an independent risk factor of death in MHD patients. Monitoring the follow-up tCO2 level may predict the occurrence of all-cause death in MHD patients. Improving blood tCO2 level can reduce all-cause death in MHD patients.

       

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