Objective To explore the relationship between the of neutrophils to lymphocytes ratio (NLR) and platelet distribution width(PDW) in peripheral blood and Child-Pugh grading in patients with liver cirrhosis complicated with gastroesophageal variceal bleeding(GEVB).

Methods A total of 84 patients with liver cirrhosis complicated with GEVB were selected as the observation group, and 64 healthy people were set as the control group. According to Child-Pugh grading standard, the patients with liver cirrhosis were divided into the A, B and C grades(38 cases in grade A, 25 cases in grade B and 21 cases in gradeC, respectively). Patients with liver cirrhosis were divided into the bleeding group(53 cases) and non-bleeding group(31 cases) according to whether they were complicated with variceal bleeding. The NLR and PDW were measured. The Child-Pugh grades A, B and C were compared between the observation group and control group. The differences in the above indicators between the bleeding group and non-bleeding group, and amount of blood lost in the bleeding group were compared.

Results The NLR and PDW in the observation group were higher than those in the control group(P < 0.01). The worse the Child-Pugh grade, the higher the NLR, which was positively correlated with Child-Pugh grading(P < 0.01). The NLR in the bleeding group was higher than that in non-bleeding group(P < 0.01). The greater the amount of bleeding, the higher the NLR (P < 0.01). There was no statistical significance between PDW and bleeding(P>0.05).

Conclusions The change of NLR in peripheral blood is related to the Child-Pugh grading in patients with liver cirrhosis complicated with GEVB. The higher the Child-Pugh grading, the higher the NLR level. In clinical work, the degree of patients' illness is predicted according to the level of peripheral blood NLR, which provides a strong basis for prognosis evaluation and clinical treatment of patients.