Objective To investigate the diagnostic value of combined detection of human serum chitinase-3-like protein 1(YKL-40), Krüppel-like factor 5(KLF5) and connective tissue growth factor(CTGF) in the endometrial endometrioid carcinoma(EEC).

Methods Eighty-eight patients with EEC A total of from 2020 to 2021, and 84 patients with normal physical examination were divided into the EEC group and control group. The enzyme-linked immunosorbent assay was used to detect the levels of serum YKL-40, KLF5, and CTGF in EEC patients. The immunohistochemistry was used to detect the levels of YKL-40, KLF5, and CTGF in EEC patients' cancer tissues and adjacent tissues. Multivariate logistic regression was used to analyze the risk factors for EEC occurrence. ROC curve was used to analyze the diagnostic value of serum YKL-40, KLF5, and CTGF levels for EEC.

Results Compared with the control group, the expression levels of serum YKL-40, KLF5 and CTGF in the EEC group obviously increased(P < 0.01). The area under the ROC curve(AUC) of combined diagnosis of YKL-40, KLF5, and CTGF was obviously larger than that of YKL-40(Z=3.448, P < 0.01), KLF5(Z=3.885, P < 0.01) and CTGF(Z=3.101, P < 0.01). Compared with adjacent tissues, the positive expressions of YKL-40, KLF5 and CTGF in EEC cancer tissues obviously increased(P < 0.05 to P < 0.01). The expressions of YKL-40, KLF5, and CTGF were related to the degree of EEC differentiation, FIGO stage and lymph node metastasis(P < 0.05 to P < 0.01). The results of multivariate logistic regression analysis showed that the high levels of YKL-40, KLF5 and CTGF were the risk factors of EEC(P < 0.05 to P < 0.01).

Conclusions The expression levels of serum YKL-40, KLF5 and CTGF in EEC patients elevate, and the three are the risk factors of affecting the occurrence of EEC. The combination of the three has a high diagnostic value for EEC.