Objective To investigate the levels of serum chemokine C-C-motif ligand 1 (CCL-1) and soluble human leukocyte antigen-G (sHLA-G) in pregnant women with preeclampsia and their predictive value for pregnancy outcomes.

Methods A total of 168 pregnant women with preeclampsia were selected and divided into a poor outcome group (n=37) and a good outcome group (n=131) based on pregnancy outcomes.Enzyme-linked immunosorbent assay was used to measure serum CCL-1 levels, and double antibody sandwich assay was used to measure sHLA-G levels.The factors that affected adverse pregnancy outcomes, evaluate the predictive value of serum CCL-1 and sHLA-G levels on pregnancy outcomes were analyzed, and the relationship between serum CCL-1 and sHLA-G levels and pregnancy outcomes was analyzed.

Results The CCL-1, systolic blood pressure at admission, diastolic blood pressure at admission, uric acid, bile acid, and hemoglobin levels of pregnant women in the poor outcome group were higher than those in the good outcome group, sHLA-G, the serum albumin level, platelet count, and proportion of delayed type were lower in the good outcome group (P < 0.01).CCL-1, sHLA-G, serum albumin were contributing factors to adverse pregnancy outcomes in pregnant women with preeclampsia (P < 0.05).The AUC of predicting adverse pregnancy outcomes in pregnant women with preeclampsia by combining serum CCL-1 and sHLA-G levels was greater than that of detecting CCL-1 and sHLA-G separately (P < 0.01).The incidence of adverse pregnancy outcomes in pregnant women with high levels of CCL-1 was higher than that in pregnant women with low levels of CCL-1, and the incidence of adverse pregnancy outcomes in pregnant women with high levels of sHLA-G was lower than that in women with low levels of sHLA-G (P < 0.01).

Conclusions Serum levels of CCL-1 and sHLA-G are closely related to pregnancy outcomes in pregnant women with preeclampsia, and their combination has good predictive value for evaluating patients′ pregnancy outcomes.