Objective To explore the clinical effect of uterine artery occlusion combined with myomectomy and its impact on the function of ovarian reserve.

Methods A total of 102 patients diagnosed with uterine fibroids were randomly assigned to either the control group or the observation group, 51 cases in each group. The control group underwent laparoscopic myomectomy, while the observation group underwent uterine artery occlusion combined with myomectomy. The surgical indicators, interleukin-1 (IL-1), interleukin-6 (IL-6), serum tumor necrosis factor α (TNF-α), serum luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E₂), the number of antral follicles, and the incidence of complications were observed in the two groups.

Results The observation group had lower intraoperative blood loss than the control group (P ＜ 0.01); three days post-surgery, the levels of IL-1, IL-6, and TNF-α in the observation group were lower than those in the control group (P ＜ 0.01); there was no statistical difference in the levels LH, FSH, E₂ and number of sinus follicles in the two groups before surgery, 1 month after surgery and 3 months after surgery (P ＞ 0.05); and there was no statistical difference in the incidence of incision infection, pelvic infection, poor incision healing and abnormal menstruation between the two groups (P ＞ 0.05).

Conclusions Uterine artery blocking combined with hysteromyoma resection can reduce the amount of intraoperative bleeding and reduce inflammatory reactions, have little impact on hormone levels and ovarian reserve function, lower incidence of postoperative complications, and high clinical promotion and application value.