Abstract: Objective: To evaluate the clinical therapeutic effect of noninvasive positive-pressure ventilation (NIPPV) in treating chronic obstructive pulmonary disease(COPD) with respiratory failure. Methods: Of 56 COPD patients with respiratory failure were randomly divided into treatment group and control group. The control group was routinely treated with anti-infection,relieving cough and reducing sputum,relieving asthma,and continuous low-flow oxygen therapy. Based on the conventional therapy,the treatment group was added NIPPV. After 48 hours,the two group was observed on the part of arterial blood-gas,heart rate,breathing rate,then compared and analysed. Results: After NIPPV,the arterial PaO₂ was elevated gradually,the PaCO₂ was declined gradually and the result of PH was improved. The heart rate and breathing rate was declined(P < 0.05). The results of the two groups were different evidently(P < 0.05). Conclusions: It is effective to treat chronic obstructive pulmonary disease with respiratory failure with NIPPV on the part of improvement of meionectic blood,respiratory function,symptom.