Abstract:
Objective To investigate the effects of combined treatment with rosuvastatin and irbesartan on the levels of serum retinol-binding protein-4 (RBP-4) and secreted protein acidic and rich in cysteine (SPARC) in elderly hypertensive patients.
Methods Ninety-six elderly hypertensive patients were selected, and randomly divided into 2 groups, with 48 cases in each group. The control group was treated with irbesartan, and the observation group received rosuvastatin in addition to irbesartan. The blood pressure, vascular endothelial functionvascular endothelial growth factor (VEGF), nitric oxide (NO), endothelin-1 (ET-1), serum levels of RBP-4 and SPARC and incidence of adverse reactions were compared between two groups.
Results After treatment, the diastolic blood pressure and systolic blood pressure in the observation group were lower than those in control group (P ＜ 0.05). The NO level of the observation group was higher than that of control group, and the ET-1 and VE GF levels were lower than these of control group (P ＜0.05). The RBP-4 and SPARC levels in the observation group were lower than these of control group (P ＜0.05). There was no statistical significance in the incidence of adverse reactions between two groups (P ＞ 0.05).
Conclusions Rosuvastatin combined with irbesartan can effectively reduce the blood pressure, improve the vascular endothelial function, and reduce the degree of arterial atherosclerosis and vascular inflammatory response by lowering the serum levels of RBP-4 and SPARC in elderly hypertensive patients.
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