Abstract: Objective: To investigate the difference of the risk factors of coronary heart disease(CHD) complicated with depression and post stroke depression(PSD),and provide the reference for preventing and treating CHD and PSD etiology.Methods: The general data and clinical data of patients with CHD and stroke were collected,the risk factors of which were analyzed using univariate and multivariate Logistic regression analysis.Results: The differences of gender,age,occupation,economic status,smoking and alcohol consumption between two groups were statistically significant using univariate analysis(P<0.05).Logistic regression analysis showed that the effects of male and hypertension on PSD patients were greater than that on CHD patients with depression(P<0.05 and P<0.01),and the effects of older and occupation on CHD patients with depression were greater than that on PSD patients(P<0.05).Conclusions: The risk factors of CHD depression and PSD are different.