Abstract: Objective: To explore the effects of self-efficacy and self-care intervention on the quality of life of postoperative patients with laryngocarcinoma.Methods: Seventy-nine patients with laryngocarcinoma diagnosed by pathology from the E.N.T.department of a top three hospital were divided into the observation and control group.The control group and observation group were nursed with routine nursing and self-efficacy and self-care on the basis of the routine nursing,respectively.The intervention effects were evaluated using the General Self-Efficacy Scale,the exercise of Self-care Agency and the Chinese quality of life instrument for cancer patients-head and neck cancer.Results: The ability of self-efficacy and self-care and quality of life of patients in observation group increased,which were better than those in control group(P<0.01).The scores of self-efficacy and self-care ability in observation group were improved as time went on(P<0.01),The differences of the scores of quality of life in patients between the preoperation,discharge and after the intervention were statistically significant(P<0.05 to P<0.01).Conclusions: The joint nursing intervention can significantly improve the ability of self-efficacy and self-care and quality of life of patients with laryngocarcinoma.