Abstract: Objective: To evaluate the safety and efficacy of transurethral plasmakinetic resection of prostate(TUPKRP) for treatment of benign prostatic hyperplasia(BPH). Methods: The 120 cases of BPH were treated by TUPKRP,the cutting method was performed according to the size of gland. The international prostate symptom score(IPSS),quality of life(QOL),maximum flow rate(Qmax), postvoid residual volume(PRV) of preoperation and postoperation were observed and statistically analyzed. Results: All cases were treated successfully. The operative time was 30-200 min,the weight of resected tissue was 10-100 g,the intraoperative blood loss was 30-200ml,the bladder irrigating time after operation was 2-6 d,the duration of catheter was 3-7 d,and the hospital stay after operation was 5-16 d. There was no operative death,no blood transfusion was required,and no perforation of the prostatic capsule, obturator nerve reflex and transurethral resection syndrome (TURS) occurred. All patients were followed up for 3-12 months postoperatively,there were no serious complications. The differences of IPSS, QOL, Qmax and PRV between preoperation and postoperation were statistically significances(P < 0.01). Conclusions: TUPKRP is a safe and effective method for treatment of BPH,it is worth popularizing.