CT perfusion imaging in preoperative grading of astrocytoma
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摘要: 目的:探讨CT灌注成像(CT perfusion imaging,CTP)在脑星形细胞瘤术前分级中的作用。方法:经手术及病理证实的脑星形细胞瘤31例,其中低级别星形细胞瘤14例,高级别星形细胞瘤17例。行常规CT及CTP检查,构建分析脑血流量(CBF)、血容量(CBV)及表面通透性(PS)图像,计算平均CBF、CBV及PS值。并分别在病变对侧脑组织中区测定正常区域的各相应值,分析各组间灌注数据,进行统计学分析。结果:脑星形细胞瘤的CBF、CBV及PS值较对侧正常脑组织均明显升高(P<0.01)。高级别星形细胞瘤病变区的CBF、CBV、PS值明显高于低级别星形细胞瘤病变区(P<0.01)。星形细胞瘤病变区的CBF、CBV及PS值均呈正相关关系(P<0.01)。结论:CTP对星形细胞瘤术前分级有较高的临床应用价值。
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关键词:
- 脑肿瘤 /
- 星形细胞瘤 /
- 灌注成像 /
- 体层摄影术,X线计算机 /
- 病理学,临床
Abstract: Objective: To evaluate the role of CT perfusion imaging(CTP) in preoperative grading of astrocytoma.Methods: CTP was performed in 31 patients with astrocytioma.Forteen cases were proved to be low-grade astrocytoma and 17 cases high-grade astrocytoma.All the cases received CT and CTP examinations.The cerebral blood flow(CBF),cerebral blood volume(CBV) and permeability surface(PS) values were calculated,and the perfusion maps were statistically analyzed.Results: The CBF,CBV and PS value of the astrocytoma were higher than that of the normal brain tissue(P<0.01).The CBF,CBV and PS value of high grade astrocytoma were higher than that of low grade astrocytoma(P<0.01).There was a positive correlation among the CBF,CBV and PS value in the astrocytoma(P<0.01).Conclusions: CTP has great clinical value in preoperative grading of astrocytoma.-
Keywords:
- brain neoplasms /
- astrocytoma /
- perfusion imaging /
- tomography,X-ray computed /
- pathology,clinical
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