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    急性白血病患者血管性血友病因子抗原检测的临床价值

    The clinical significance of von willebrand factor antigen detection in patients with acute leukemia

      摘要
    • 摘要: 目的:初步探讨急性白血病(AL)患者血管性血友病因子抗原(vWF:Ag)检测的临床意义。方法:39例AL患者(AL组),外周血白细胞计数>50×109 /L 15例,<50×109/L 24例,21名健康体检者为正常对照组(对照组)。使用CA-7000血凝仪检测vWF:Ag、D-二聚体及纤维蛋白(原)降解产物(FDPs);使用7600型生化分析仪检测乳酸脱氢酶(LDH)和超敏C反应蛋白(hs-CRP);全血细胞计数采用迈瑞6800型血细胞分析仪。结果:AL组的vWF:Ag、D-二聚体、FDPs、LDH和hs-CRP水平均明显高于对照组(P<0.01);白细胞>50×109/L的患者vWF:Ag和LDH均高于白细胞<50×109/L的患者(P<0.05和P<0.01),vWF:Ag与D-二聚体、FDPs、LDH和hs-CRP水平均呈正相关关系(P<0.05)。结论:AL患者存在以vWF:Ag升高为表现的内皮细胞损伤,这种表现与肿瘤负荷、急性期反应和纤溶亢进有关。

       

      Abstract: Objective: To explore the clinical meaning of von willebrand factor antigen (vWF:Ag) detection in patients with acute leukemia.Methods: The levels of vWF:Ag,D-dimer and fibrin/fibrinogen degradation products(FDPs) were detected by CA-7000 coagulation analyzer,the levels of lactate dehydrogenase(LDH) and high sensitive C-reactive protein(hs-CRP) were detected by 7600 automated biochemistry analyzer,the complete blood counts were tested by Mindray 6 800 hematology analyzer in 39 patients with acute leukemia(including 15 cases with WBC>50×109 /L and 24 cases with <50×109/L) and 21 normal controls.Results: Compared with the control group,the levels of vWF:Ag,D-dimer,FDPs,LDH and hs-CRP were higher in acute leukemia patients(P<0.01),the levels of vWF:Ag and LDH were higher in acute leukemia patients with WBC>50×109 /L than those with WBC<50×109/L(P<0.05 and P<0.01),vWF:Ag had the positive correlations with D-dimer,FDPs,LDH and hs-CRP.Conclusions: The endothelial cell injury was happened in patients with acute leukemia,which presented as the increase of vWF:Ag,the manifestation was correlated with tumor load,acute phase response and hyperfibrinolysis.

       

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