马新义, 陶仪声, 马莉. 食管鳞状细胞癌中基质金属蛋白酶-1与血管内皮生长因子-C的表达及意义[J]. 蚌埠医学院学报, 2010, 35(8): 771-775.
    引用本文: 马新义, 陶仪声, 马莉. 食管鳞状细胞癌中基质金属蛋白酶-1与血管内皮生长因子-C的表达及意义[J]. 蚌埠医学院学报, 2010, 35(8): 771-775.
    MA Xin-yi, TAO Yi-sheng, MA Li. Expressions of matrix metalloproteinase-1 and vascular endothelial growth factor-C in esophageal squamous cell carcinoma and their clinical significance[J]. Journal of Bengbu Medical College, 2010, 35(8): 771-775.
    Citation: MA Xin-yi, TAO Yi-sheng, MA Li. Expressions of matrix metalloproteinase-1 and vascular endothelial growth factor-C in esophageal squamous cell carcinoma and their clinical significance[J]. Journal of Bengbu Medical College, 2010, 35(8): 771-775.

    食管鳞状细胞癌中基质金属蛋白酶-1与血管内皮生长因子-C的表达及意义

    Expressions of matrix metalloproteinase-1 and vascular endothelial growth factor-C in esophageal squamous cell carcinoma and their clinical significance

    • 摘要: 目的:探讨食管鳞状细胞癌中基质金属蛋白酶-1(MMP-1)和血管内皮生长因子-C(VEGF-C)的表达及其与食管鳞状细胞癌临床病理参数的关系。方法:应用免疫组织化学S-P法检测90例食管鳞状细胞癌组织、16例重度不典型增生/原位癌、28例癌旁正常上皮组织中MMP-1及VEGF-C的表达情况。结果:MMP-1在食管鳞状细胞癌、不典型增生/原位癌及癌旁正常组织中的阳性率分别为81.11%、81.25%及17.86%(P<0.01),其表达与食管鳞状细胞癌浸润深度、淋巴结转移以及临床分期均有一定关系,而与分化程度无明显关系(P>0.05)。VEGF-C在食管鳞状细胞癌、不典型增生/原位癌及癌旁正常组织中的阳性率分别为83.33%、75.00%及25.00%(P<0.01),其表达与食管鳞状细胞癌淋巴结转移及临床分期均有一定关系(P<0.01和P<0.05),而与分化程度及浸润深度均无明显关系(P>0.05)。两者呈正相关关系(P<0.01)。结论:MMP-1、VEGF-C两者协同促进了食管鳞状细胞癌的浸润与淋巴结转移,可作为判断食管鳞状细胞癌生物学行为的重要参考指标。

       

      Abstract: Objective: To investigate the expression of matrix metalloproteinase-1 (MMP-1) and vascular endothelial growth factor-C (VEGF-C) in human esophageal squamous cell carcinoma (ESCC),and their relationship with the clinicopathological parameters.Methods: The expressions of MMP-1 and VEGF-C were determined immunohistochemically in 90 cases of human esophageal squamous cell carcinoma,16 cases of severe dysplasia/carcinoma in situ and 28 cases of adjacent normal tissues.Results: The positive expression rates of MMP-1 in ESCC,severe dysplasia/carcinoma in situ and adjacent normal tissues were 81.11%,81.25% and 17.86%,respectively.The expression of MMP-1 was associated with the depth of invasion,lymph node metastasis and clinical staging in ESCC,but not with differentiation (P>0.05).The positive expression rates of VEGF-C in ESCC,severe dysplasia/carcinoma in situ and adjacent normal tissues were 83.33%,75.00% and 25.00%,respectively (P<0.01);the expression of VEGF-C was associated with the lymph node metastasis and clinical staging in ESCC (P<0.01 and P<0.05),but not with the differentiation or depth of invasion (P>0.05).And there was a positive correlation between MMP-1 and VEGF-C (P<0.01).Conclusions: MMP-1 and VEGF-C play a crucial role in invasion and lymphatic metastasis.They are important predictors of biological behavior in ESCC.

       

    /

    返回文章
    返回