章再军, 周倩, 吴慧. 乳腺原发弥漫性大B细胞淋巴瘤2例报道并文献复习[J]. 蚌埠医科大学学报, 2011, 36(2): 139-141.
    引用本文: 章再军, 周倩, 吴慧. 乳腺原发弥漫性大B细胞淋巴瘤2例报道并文献复习[J]. 蚌埠医科大学学报, 2011, 36(2): 139-141.
    ZHANG Zai-jun, ZHOU Qian, WU Hui. Primary diffuse large B cell lymphoma of the breast: 2 cases report and review of the literatures[J]. Journal of Bengbu Medical University, 2011, 36(2): 139-141.
    Citation: ZHANG Zai-jun, ZHOU Qian, WU Hui. Primary diffuse large B cell lymphoma of the breast: 2 cases report and review of the literatures[J]. Journal of Bengbu Medical University, 2011, 36(2): 139-141.

    乳腺原发弥漫性大B细胞淋巴瘤2例报道并文献复习

    Primary diffuse large B cell lymphoma of the breast: 2 cases report and review of the literatures

    • 摘要: 目的:探讨乳腺原发性弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)的临床及病理形态学特点、组织发生、诊断及鉴别诊断。方法:应用免疫组织化学染色及形态学观察对2例乳腺原发性DLBCL进行分析,并复习文献。结果:2例均发生于左乳房,发病年龄分别为46及42岁,肿块境界清楚,组织学为肿瘤细胞弥漫浸润,核圆形或不规则形,部分瘤细胞核明显大,伴凋亡现象及小灶性坏死,部分区见小淋巴细胞散在。结论:原发于乳腺的DLBCL是一种罕见结外起源的DLBCL,形态及发生机制与其他部位的DLBCL类似,免疫组织化学技术结合大体标本及镜下形态学观察有助于与乳腺癌、肉瘤的鉴别。

       

      Abstract: Objective: To investigate the clinical pathologic characteristics,histogenesis,diagnosis and differential diagnosis of primary diffuse large B-cell lymphoma (DLBCL) of the breast. Methods: Two cases of breast DLBCL were analyzed by immunohistochemistry and morphology,and the related literatures were reviewed. Results: Two patients both noticed a mass in their left breast,and their ages were 46 and 42 years. The tumors were well circumscribed accompanied by the focal region proliferation response of lymphocyte. The tumor cells widespreadly infiltrated in the surrounding tissue. The nucleus of tumor cells were round, irregular and unusual large, accompanied by apoptosis and focal necrosis. Conclusions: Primary DLBCL of the breast,which the tumorgenesis and morphology are similar to lymphoma in other parts,is a rare subtype lymphoma of non-lymph node origin. The recent development of immunohistochemical markers may be useful to distinguish the breast cancer and sarcoma in addition to conventional histological criteria for diagnosis.

       

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