Abstract: Objective: To investigate the correlation between plasminogen activator inhibitor-1(PAI-1) and diabetic foot,and to provide references for the prevention and treatment of diabetic foot(DF). Methods: Forty-two patients with DF were included in the DF group, 38 diabetes mellitus(DM) with non-DF were DMNDF group,and 45 volunteers were selected as control. The plasma concentration of PAI-1,glycosylated hemoglobin (HbA1c) and C reactive protein (CRP) were compared among the groups. Results: There were statistically significant differences among the DF group,control group and DMNDF groups in PAI-1,HbA1c and CRP(P < 0.05-P < 0.01). Conclusions: PAI-1 is obviously correlated with the DF. Active interference and therapy for type 2 DM could decrease the PAI-1,increase the fibrinolytic activity and inhibit the progression of atherosclerosis,thus reducing the incidence of the DF.