Abstract: Objective: To investigate the safety and effect of palatorrhaphy in cleft palate repair on infants. Methods: One hundred and eighteen cases of infants,from 5 to 18 month,were included. Two-flap was adopted as main method in operation,but combined with method of vomer bone flap repaire in complete cleft palate and. The improved Langenbeck method was adopted in incomplete cleft palate and cleft soft palate. The high frequency electric knife was used to stop bleeding. The oropharynx ventiduct was detained in oral cavity after operation. Results: One hundred and eighteen cases were safety during the anesthesia and operation. There was no severe complication during and after the operation. The infants all received primary healing except 3 cases of incision erosion,2 cases of palate perforation. After followed up,nearly 90% infants in 87 cases received good speech sound recovery to or near the level of normal children after surgery. Conclusions: The infant palatorrhaphy is safety and effective,as long as a fine anesthesia and practiced operation are given.