Objective To investigate the correlation between plasma homocysteine (Hcy) levels and left ventricular ejection fraction (LVEF) in patients with stable angina pectoris.

Methods Patients who were first diagnosed with stable angina pectoris, and admitted to the First Affiliated Hospital of Xi 'an Jiaotong University from June 2014 to January 2015 were selected as the research subjects. Morning fasting elbow venous blood was collected to determine the plasma Hcy level. A Hcy level ＞ 15μmol/L was diagnosed as hyperhomocysteinemia (Hhcy), and the LVEF value was measured by color Doppler ultrasound. The covariates such as the patient's gender, age, physical exercise, smoking, drinking, hypertension, diabetes, systolic blood pressure, diastolic blood pressure, body mass index, total cholesterol, triglycerides, high–density lipoprotein cholesterol and low–density lipoprotein cholesterol were collected. The relationship between LVEF values and plasma Hcy levels was analyzed using simple linear regression analysis and multivariate linear regression analysis.

Results A total of 124 patients with stable angina pectoris were ultimately included in this study for analysis, among whom 74 were male (59.7%), with an age of (65.74 ± 8.71) years, and the plasma Hcy level was 15.80(13.12, 21.42)μmol/L. There were 66 cases (53.2%) of Hhcy, with LVEF for (66.88 ± 5.99) %. The results of univariate analysis showed that the LVEF level in the Hhcy group was lower than that in normal Hcy group (P ＜ 0.05). The results of simple linear regression (B = –2.495, 95%CI: –4.569 to –0.421, P ＜ 0.05) and multivariate linear regression (B = –2.407, 95%CI: –4.432 to –0.382, P ＜ 0.05) both suggested that Hhcy was negatively correlated with LVEF.

Conclusions In patients with stable angina pectoris, Hhcy is independently associated with a lower LVEF, suggesting that it may be a potential risk factor for the reduction of LVEF.