Abstract: Objective: To explore the molecular classification in breast cancer and the clinicopathological features of variant subtypes.Methods: The expression of ER,PR and HER2 (C-erbB-2) in the cases of breast cancer detected immunohistochemically (S-P method) were studied retrospectively.The cases were reclassified according to the standard of molecular classification,and the clinicopathological features were observed and compared with the WHO histological classification.Results: The invasive breast carcinomas 745 cases were divided into 5 subtypes according to the molecular classification.Among these cases,luminal A subtype accounted for 235 cases,luminal B subtype 95 cases,HER2 overexpressing subtype 141 cases and basal-like subtype (BLBC)/triple negative breast cancer 142 cases,respectively.The remainder was not classified.The clinicopathological features were described.Conclusions: The moleculai and histological classifications of breast cancer are partly responsive.Immuohistochemical technique is helpful standardization to the molecular classification,which is more directly related to the therapy and prognosis and so worthy of wide employment and further standardization.