李学超. 唑来膦酸联合化疗治疗恶性肿瘤骨转移32例临床分析[J]. 蚌埠医学院学报, 2014, 39(9): 1214-1215.
    引用本文: 李学超. 唑来膦酸联合化疗治疗恶性肿瘤骨转移32例临床分析[J]. 蚌埠医学院学报, 2014, 39(9): 1214-1215.
    LI Xue-chao. Clinical efficacy of zoledronic acid combined with chemotherapy in the treatment of malignant tumor with bone metastases[J]. Journal of Bengbu Medical College, 2014, 39(9): 1214-1215.
    Citation: LI Xue-chao. Clinical efficacy of zoledronic acid combined with chemotherapy in the treatment of malignant tumor with bone metastases[J]. Journal of Bengbu Medical College, 2014, 39(9): 1214-1215.

    唑来膦酸联合化疗治疗恶性肿瘤骨转移32例临床分析

    Clinical efficacy of zoledronic acid combined with chemotherapy in the treatment of malignant tumor with bone metastases

    • 摘要: 目的:观察唑来膦酸联合化疗对恶性肿瘤骨转移的临床疗效及不良反应。方法:将64例恶性肿瘤骨转移患者随机分为2组,其中对照组32例单用化疗;治疗组32例接受唑来膦酸联合化疗,2组化疗方案相同。结果:治疗组疼痛总有效率81.3%,对照组为46.9%。治疗组骨病灶控制总有效率62.5%,对照组为28.1%;治疗组均优于对照组(P<0.01)。2组无严重不良反应发生。结论:唑来膦酸联合化疗治疗恶性肿瘤骨转移疗效确切,优于单用化疗,且不良反应少,患者依从性好。

       

      Abstract: Objective: To investigate the effects and adverse reactions of zoledronic acid combined with chemotherapy in the treatment of malignant tumor with bone metastases.Methods: Sixty-four malignant tumor patients with bone metastases were randomly divided into the control group and trial group(32 cases each group).The control group and trial group were treated with single chemotherapy and zoledronic acid combined with chemotherapy,respectively.The chemotherapy regimens of two groups were the same.Results: The totally effective rates of curing pain in trial group and control group were 81.3% and 46.9%,respectively.The totally effective rates of controlling bone metastases in trial group and control group were 62.5% and 28.1%,respectively.The treatment effect in trial group was better than that in control group(P<0.01),no serious adverse reaction in two groups was found.Conclusions: The therapeutic effect of zoledronic acid combined with chemotherapy is better than that of single chemotherapy.The adverse reaction of zoledronic acid combined with chemotherapy is slight,and the patient is well-tolerated.

       

    /

    返回文章
    返回