SLE患者妊娠期并发多脏器功能障碍综合征7例临床分析

Clinical analysis of pregnancy-induced systemic lupus erythematosus complicated by multiple organ dysfuntion syndromes: A report of 7 cases

摘要: 目的: 探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者妊娠期并发多脏器功能障碍综合征(mutiple organ dysfunctiong syndrome,MODS)的预防与诊治。方法: 对7例SLE妊娠期引起的多脏器功能损害临床资料进行回顾性分析。结果: 2例妊娠前已确诊为SLE,5例入院后确诊SLE。孕产妇抢救成功6例,1例放弃治疗,围生儿死亡6例。结论: SLE患者妊娠并发多脏器功能障碍对孕产妇及围生儿危害极大,处理的关键是尽早确诊并积极治疗原发病;适时终止妊娠,保护相关脏器功能和全身支持疗法至关重要。

Abstract: Objective: To investigate the prevention,diagnosis and treatment of the multiple organ failure in pregnant women with systemic lupus erythematosus(SLE).Methods: The clinical data of 7 cases of multiple organ failure induced by pregnancy SLE were analyzed retrospectively.Results: Two cases were diagnosed as SLE before pregnancy and 5 cases were diagnosed during hospital stay.Among them,6 cases were rescued and 1 case gave up.Six neonates died.Conclusions: The key to the treatment of pregnancy-induced SLE complicated by multiple organ failure are prompt diagnosis,effective treatment of the primary disease,timely termination of pregnancy,protection of the organ's function and intensifying the supportive therapy.