多西他赛联合顺铂治疗晚期乳腺癌临床观察

Docetaxel combined with cisplatin for treatment of advanced breast cancer

摘要: 目的: 观察多西他赛联合顺铂治疗晚期乳腺癌的近期疗效与不良反应。方法: 47例晚期乳腺癌患者应用多西他赛70mg/m²静脉滴注1 h,第1天,用药前24 h口服地塞米松7.5 mg,每天2次,连用3天;顺铂25~30 mg/m²静脉滴注,第1~4天,每21天为1周期。结果: 完全缓解5例,部分缓解29例,总有效率72.3%。不良反应主要为中性粒细胞减少、恶心、呕吐等。结论: 多西他赛与顺铂联用治疗晚期乳腺癌疗效显著、耐受性好。

Abstract: Objective: To observe the clinical response and side effect of docetaxel combined with cisplatin in treatment of advanced breast cancer.Methods: All the patients were administered docetaxel 70 mg/m² iv drip d1,and dexamethasone 7.5 mg bid d1-3 twenty-four hours before chemotherapy.Cisplatin 25-30 mg/m² was given iv drip d1-3,every 3 weeks as a circle.Results: Five cases presented complete remission(CR),and 29 cases partial remission(PR).The total response rate(PR+CR) was 72.3%.The main toxicity was neutropenia,nausea and vomiting.Conclusions: The regimen of docetaxel combined with cisplatin has significant antitumor activity for patients with advanced breast cancer.