Abstract: Objective:To investigate the safety and efficacy of the transurethral plasma kinetic resection of the patients with prostatic hyperplasia size. Methods:Forty-one patients with benign prostate hyperplasia were treated by transurethral bipolar plasmakinetic prostatectomy and their clinical data were retrospectively summarized. Results:The mean operation time was(82.5±9.2) minutes,and the mean blood loss was(195.5±65.8) ml. 3 cases were complicated with urethrostenosis,but no patient exhibited clinical sign of (transurethral resection syndrome. All cases were folowed up for 24 months,The Qmax elevated from(4.2±0.5) ml/s to(22.6±2.5) ml/s(P<0.01) and the postvoid residual volume reduced from(104.2±21.5) ml to(29.3±6.2) ml(P<0.01). The score of international prostate syndrome score and quality of life reduced from 26.4±3.6 and 5.1±0.3 to 8.7±2.4 and 2.5±0.4, respectively(P<0.01). Conclusions:transurethral plasma kinetic resection is safe and effective for the treatment of large prostate.