Abstract: Objective: To observe the curative effect of proximal femoral nail-A anti-rotation (PFNA) in treating multisegmental femoral fracture of proximal femur by a new interlocking nail. Methods: Twenty-one cases with multisegmental of femur fractures of proximal femur had been treated with PFNA. The surgery was operated on orthopedic lower limb automatic traction bed,PENA was fulfilled under C-arm fluoroscopy monitoring. Results: The 21 cases were followed up for 6 to 24 months. All cases were well union. The average healing time was 4.8 months,except two patients' recovery was delayed. However,all of them had healed 6 months after PFNA was removed,and the function of hip and knee were well recovered. According to the recovery evaluation criteria of national femoral fracture,12 cases were excellent,7 were good,and 2 were poor. The acceptance rate was 90.5%. The major nail in one case was slightly curved,but the function was not affected. Conclusions: PFNA is a reliable fixation method for multisegmental fracture of femur from subtrochanteric to femoral condyle with less trauma and blood loss.