Abstract: Objective: To investigate the relationships among the levels of plasma homocysteine(Hcy),N-terminal prohormone of brainnatriuretic(NT-proBNP),high sensitivity C reactive protein(hs-CRP) and ischemic stroke(IS) onset and recurrence,and provide the scientific basis for clinical diagnosis,condition assessment and prognosis.Methods: Total 216 patients with IS from Dec.2011 to Aug.2013 were recruited,134 cases with IS initial onset,and 82 cases with recurrence,meanwhile 100 healthy persons were selected as control group.Plasma Hcy,NT-proBNP and hs-CRP levels in the three groups were measured.The factors in IS initial onset and recurrence were carried out in multiple logistic regression analysis.Results: The plasma Hcy,NT-proBNP and hs-CRP levels in primary and recurrent IS patients were significantly higher than that in control group(P<0.01);Hcy,NT-proBNP and hs-CRP levels in the recurrence group were significantly higher than that in the initial onset group(P<0.01);Hcy,NT-proBNP and hs-CRP levels in recurrent group accounted for 56.10%,38.06% and 74.39% above the normal range,which were significantly higher than 38.06%,26.87% and 36.57% in primary group(P<0.01);the multiple logistic regression analysis results displayed the rise of Hcy,NT-proBNP and hs-CRP levels were IS independent risk factors for the inifial onset(P<0.01);diabetes and the rise of Hcy,NT-proBNP and hs-CRP levels were the independent risk factors for the recurrence of IS(P<0.01).Conclusions: Plasma Hcy,NT-proBNP,hs-CRP levels in IS patients are significantly higher than in healthy people,and Hcy,NT-proBNP,hs-CRP levels in the recurrence IS are also higher than in the initial onset.High levels of Hcy,NT-proBNP and hs-CRP are all IS independent risk factors for recurrence.