左卡尼汀治疗非酒精性脂肪肝32例胰岛素抵抗变化

    The effect of L-carnitine on insulin resistance of 32 cases with nonalcoholic fatty liver

    • 摘要: 目的:探讨左卡尼汀(LC)治疗非酒精性脂肪肝(NAFLD)的疗效。方法:62例NAFLD患者,随机分为LC治疗组(LC组)32例和安慰剂对照组30例,LC组予LC口服,每次1 g,早晚饭后各1次,疗程共24周。记录治疗前后患者血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、-谷氨酰转肽酶(GGT)、三酰甘油(TG)、总胆固醇(TC)、C反应蛋白(CRP)、空腹血糖(FBG)、胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)水平,以及肝脏超声表现。结果:与治疗前和对照组比较,LC组治疗后ALT、AST、GGT、TG,TC、FINS、HOMA-IR值均明显降低(P0.01),肝脏B超明显改善,总有效率明显高于对照组(P0.01)。结论:左卡尼汀可有效改善NAFLD患者肝功能、血脂,减轻胰岛素抵抗,能安全有效地用于治疗NAFLD。

       

      Abstract: Objective:To explore of the effects of L-carnitine(LC) in the treatment of nonalcoholic fatty liver disease(NAFLD).Methods:Sixty-two patients with NAFLD were randomly divided into the LC treatment group(LC group)(32 cases) and placebo control group(30 cases). The LC group were treated with 1 g of LC by oral,twice a day for 24 weeks after breakfast and dinner. The levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),-glutamyltransferase(GGT),triglyceride(TG),total cholesterol(TC),C reactive protein(CRP),fasting plasma glucose(FBG),insulin(FINS),insulin resistance index(HOMA-IR) and liver ultrasound in all patients were recorded before and after treatment.Results:Compared with the before treatment and control group,the levels of ALT,AST and GGT,TG and the TC,FINS and HOMA-IR of LC group decreased significantly(P0.01),and the liver B ultrasound was improved obviously after treatment. The total effective rate of the LC group was significantly higher than that in control group(P0.01).Conclusions:L-carnitine can effectively improve the liver function and blood lipid,and reduce the insulin resistance of patients with NAFLD,which is a safe and effective drug in the treatment of NAFLD.

       

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