宋珂, 王华明. 奥拉西坦联合尼莫地平治疗血管性痴呆疗效观察[J]. 蚌埠医科大学学报, 2014, 38(5): 601-602.
    引用本文: 宋珂, 王华明. 奥拉西坦联合尼莫地平治疗血管性痴呆疗效观察[J]. 蚌埠医科大学学报, 2014, 38(5): 601-602.
    SONG Ke, WANG Huaming. Efficacy of oxiracetam combined with nimodipine for treatment of vascular dementia[J]. Journal of Bengbu Medical University, 2014, 38(5): 601-602.
    Citation: SONG Ke, WANG Huaming. Efficacy of oxiracetam combined with nimodipine for treatment of vascular dementia[J]. Journal of Bengbu Medical University, 2014, 38(5): 601-602.

    奥拉西坦联合尼莫地平治疗血管性痴呆疗效观察

    Efficacy of oxiracetam combined with nimodipine for treatment of vascular dementia

    • 摘要: 目的:探讨奥拉西坦联合尼莫地平治疗血管性痴呆(VD)的疗效。方法:将44例VD患者随机分为观察组和对照组各22例。在基础治疗的同时对照组加服尼莫地平,每次40 mg,每天3次;观察组采用尼莫地平(用法与剂量同对照组)联合奥拉西坦4.0 g加入0.9%氯化钠注射液250 ml静脉滴注,每天1次。2组均连续用药3周。比较2组总有效率和不良反应。结果:观察组总有效率为95.45%,高于对照组的81.82%(P<0.05)。观察组与对照组不良反应发生率分别为13.64%和9.09%,差异无统计学意义(P>0.05)。结论:奥拉西坦联合尼莫地平治疗VD效果显著,安全性较好,具有临床应用价值。

       

      Abstract: Objective:To investigate the curative effect of oxiracetam combined with nimodipine in the treatment of vascular dementia(VD).Methods:Forty-four VD patients were randomly divided into observation group and control group,with 22 cases in each.The control group were administered nimodipine 40mg,3 times per day for 3 weeds in addition to the basic therapy;the observation group were given nimodipine(the same dosage and usage with the control group) combined with oxiracetam 4.0g and 250ml 0.9% sodium chloride injection intravenous drip one time a day for 3 weeks.The total effective rate and adverse reaction of the two groups were observed and compared.Results:The total effective rate was 95.45% in the observation group,which was higher than that 81.82% in the control group(P0.05).The adverse reaction rates in the observation group and control group were 13.64% and 9.09%,respectively.The incidence of adverse reaction had no statistical difference between the two groups(P0.05).Conclusions:Oxiracetam combined with nimodipine is obviously effective and safe in the treatment of VD.It is of value for clinical application.

       

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