Abstract: Objective:To explore the effect of entecavir combined with a-2b interferon(a-2b IFN) on the treatment of chronic hepatitis B(CHB).Methods:Ninety CHB patients were randomly divided into three groups:entecavir group(group A),a-2b IFN group(group B) and entecavir combined with a-2b IFN group(group C),30 cases each group.The course of the treatment in every group was 48 weeks.The changes of serum alanine aminotransferase(ALT) level,HBV DNA and the five items of hepatitis at 12th week,24th week and 48th week after treatment were monitored respectively.Results:After treatment for 12 weeks,there were no statistical differences(P＞0.05)among the three groups about the following four indexes,the negative rate of HBV DNA,the negative conversion ratio of HBeAg,the seroconversion ratio of HBeAg and the normalization rate of ALT.After treatment for 24 weeks,there were no statistical differences(P＞0.05)among the three groups about the negative rate of HBV DNA,the negative conversion ratio of HBeAg and the seroconversion ratio of HBeAg.The normalization rate of ALT in group C was higher than in group B(P＜0.05);and no statistical difference(P＞0.05)between group A and group B.After 48 week,the negative conversion ratio of HBeAg and the normalization rate of ALT in group C were higher than those in group A and group B(P＜0.05).And there were no statistical differences(P＞0.05)between group A and group B of the four indexes.Conclusions:The curative effect of entecavir combined with a-2b interferon treatment for CHB with high viral load is superior than single drug treatment.The drug combination treatment is worth promoting in the clinic.