魏芳, 尹成乐, 吴贵东, 周斌, 许瑞杰. 石榴多酚在鼠急性炎症中的保护作用[J]. 蚌埠医学院学报, 2014, 38(4): 429-432.
    引用本文: 魏芳, 尹成乐, 吴贵东, 周斌, 许瑞杰. 石榴多酚在鼠急性炎症中的保护作用[J]. 蚌埠医学院学报, 2014, 38(4): 429-432.
    WEI Fang, YIN Cheng-le, WU Gui-dong, ZHOU Bin, XU Rui-jie. The protective effect of punicosides on acute inflammation in murine[J]. Journal of Bengbu Medical College, 2014, 38(4): 429-432.
    Citation: WEI Fang, YIN Cheng-le, WU Gui-dong, ZHOU Bin, XU Rui-jie. The protective effect of punicosides on acute inflammation in murine[J]. Journal of Bengbu Medical College, 2014, 38(4): 429-432.

    石榴多酚在鼠急性炎症中的保护作用

    The protective effect of punicosides on acute inflammation in murine

    • 摘要: 目的:探讨石榴多酚(punicosides,Puns)的抗炎作用及其作用机制。方法:建立二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足跖肿胀2种急性炎症动物模型,分别设模型对照组、正常对照组、Puns干预组、吲哚美辛组;观察Puns对二甲苯致小鼠耳肿胀及角叉菜胶致大鼠足跖肿胀的抑制作用,检测Puns干预后角叉菜胶所致的大鼠足爪炎性组织中前列腺素E2(PGE2)、丙二醛(MDA)的含量及血清中超氧化物歧化酶(SOD)、MDA的含量变化。结果:Puns 400、800 mg/kg干预组均能抑制二甲苯所致的小鼠耳肿胀(P0.05和P0.01)。Puns 150、300、600 mg/kg干预组对角叉菜胶所致大鼠足跖肿胀度亦均有不同程度的抑制作用(P0.05~P0.01),Puns干预组较模型对照组可显著减少炎症组织中PGE2和MDA的产生(P0.01),Puns干预组后血清SOD活性增加,MDA含量降低,与模型组对照组差异均有统计学意义(P0.05~ P0.01)。结论:Puns具有一定的抗炎作用,其作用可能与抑制PGE2合成及抗脂质过氧化作用有关。

       

      Abstract: Objective:To explore the anti-inflammatory effects of punicosides(Puns) and its mechanism.Methods:Two kinds of acute inflammation model of mouse(including ear swelling in mice induced by dimethylbenzene and paw swelling in rats induced by carageen glue) were established,animals were divide into model control group,Puns treatment group and Indomethacin group.The inhibiting effects of Puns on mice with ear swelling induced by dimethylbenzene and rats with paw swelling induced by carageen glue were observed.The levels of the prostaglandin E2(PGE2) and methane dicarboxylic aldehyde(MDA) in rat paw and superoxide dismutase(SOD) and MDA in serum were measured in Puns treatment groups.Results:The 400 and 800 mg/kg of Puns could significantly suppress the mice ear swelling induced by dimethylbenzene(P<0.05 and P<0.01),Puns could suppress the rats paw swelling induced by carageen glue in different extents(P<0.05 to P<0.01).Compared with model control group,Puns significantly inhibited the production of PGE2 and MDA of inflammatory tissue(P0.01),increased the activity of serum SOD,and decreased the level of serum MDA,the differences of which were statistical significance(P<0.05 to P<0.01).Conclusions:Puns has anti-inflammatory effects,which may be related to the inhibition of PGE2 synthesis and anti-lipid peroxidation.

       

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