郭文静, 陈琳洁, 范晓云, 王涛, 陈静, 王信. Rhupus综合征12例临床分析[J]. 蚌埠医学院学报, 2014, 38(5): 624-626.
    引用本文: 郭文静, 陈琳洁, 范晓云, 王涛, 陈静, 王信. Rhupus综合征12例临床分析[J]. 蚌埠医学院学报, 2014, 38(5): 624-626.
    Guo Wenjing, Chen Linjie, Fan Xiaoyun, Wang Tao, Chen Jing, Wang Xin. Clinical analysis of 12 cases of Rhupus syndrome[J]. Journal of Bengbu Medical College, 2014, 38(5): 624-626.
    Citation: Guo Wenjing, Chen Linjie, Fan Xiaoyun, Wang Tao, Chen Jing, Wang Xin. Clinical analysis of 12 cases of Rhupus syndrome[J]. Journal of Bengbu Medical College, 2014, 38(5): 624-626.

    Rhupus综合征12例临床分析

    Clinical analysis of 12 cases of Rhupus syndrome

    • 摘要: 目的:探讨类风湿关节炎(RA)和系统性红斑狼疮(SLE)重叠综合征(Rhupus综合征)临床特点及诊断和治疗方法,以提高对Rhupus综合征的认识。方法:对确诊的12例Rhupus综合征患者的临床表现、血清学指标、影像学检查以及诊治情况进行回顾性分析。结果:12例Rhupus综合征患者男女比例1∶11,起病年龄23~48岁。10例患者以RA为首发表现;出现关节肿痛12例,晨僵10例,血液系统损害10例;类风湿因子定量增高9例,抗环瓜氨酸肽抗体定量增高7例,抗Sm抗体阳性8例;12例患者均发现抗核抗体阳性、红细胞沉降率及C反应蛋白增高、免疫球蛋白增高,补体下降及双手影像学改变。12例患者均采用糖皮质激素联合改善病情抗风湿药物治疗(DMARDs),病情得到有效缓解。结论:Rhupus综合征以中年女性多发,临床表现较单纯RA及SLE更为复杂,同时兼有RA及SLE临床特点,但多以RA起病常见,关节症状较重,SLE表现相对较轻,可有脏器损害,可同时或先后出现RA和SLE血清学指标,采用糖皮质激素联合DMARDs治疗能有效缓解病情。

       

      Abstract: Objective: To investigate the rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) overlap syndrome (Rhupus syndrome) methods:the clinical characteristics and diagnosis and treatment, to improve the understanding of Rhupus syndrome. Method: 12 cases of Rhupus for diagnosis of comprehensive clinical manifestations, serological indexes, imaging examination and the diagnosis and treatment of syndrome were analyzed retrospectively. Results:12 in patients with Rhupus syndrome and the proportion of 1: 11, whose age ranged from 23 to 48 years old. 10 patients had RA as the initial manifestation; 12 cases of joint pain, morning stiffness in 10 cases, 10 cases of blood system damage; quantitative increase in 9 cases of rheumatoid factor, anti cyclic citrullinated peptide antibody quantitative increase in 7 cases, anti Sm antibody was positive in 8 patients; 12 patients were found positive antinuclear antibodies, erythrocyte sedimentation rate and C reactive protein increased, immunoglobulin, complement and change hands down image. 12 cases were treated with glucocorticoid combined with disease modifying antirheumatic drugs (DMARDs), the disease has been effectively ease. Conclusion:Rhupus syndrome with multiple clinical manifestations of middle-aged women, compared with RA and SLE is more complicated, with both RA and SLE clinical features, but more to the onset of RA common, joint symptom is heavier, the SLE performance of relatively light, with organ damage, can simultaneously or successively appeared RA and SLE markers, use of glucocorticoid combined with DMARDs therapy can effectively alleviate the condition.

       

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